Factory Launch panel 
New Layout
. When using the New Layout command on the Factory Launch panel a file is created that automatically uses the factory layout template. That template matches the assigned system units for the Inventor installation. It is possible to create a factory layout with an alternate system of units using the New command.
 Click New in either the Quick Access toolbar or the 
 Application menu. A new factory layout can be created from an existing AutoCAD 2D layout. If the AutoCAD layout contains any 2D assets or chainable assets placed from the System Assets library in AutoCAD Factory, the assets are replaced with their 3D equivalents when the drawing file is opened in Inventor Factory.
On the ribbon, click 
Get Started tab
Factory Launch panel 
New Layout from DWG
drop-down menu to display the New Layout from DWG dialog box. If a factory layout is already open, click 
Factory tab
Suite Workflows panel 
Create from AutoCAD
. 
 
Get Started tab
Factory Launch panel 
New Layout from DWG in Vault
.  There is an associative link, called Layout Sync, between the 2D drawing and the 3D layout from which it was created. This link is graphically represented by the icon 
 that appears next to the drawing name node in the browser. You can remove the associativity between the DWG and the factory layout using either the Break Link or the Break Link with AutoCAD commands. 
Suite Workflows panel 
Break Link with AutoCAD
. 
 to indicate that the link is broken. Several of the command options available from the DWG browser node pop-up context menu are identical to those available after placing a DWG overlay using the Add DWG Overlay command. These options include:
For more information about the three command options above, see the Inventor Factory Help topic: Add DWG overlays
Also, please refer to the Inventor Factory Help topic: Suite Workflows to learn more about associativity between AutoCAD Factory layouts and Inventor Factory layouts.
By default, factory layout files are stored in the assigned directory of the currently active project file. If the Default project is active the files are all stored in the My Documents folder.
To learn more about using, creating, or changing the active project file, refer to the following Inventor Help documents.