During forward creation of sketched route segments, you can reorient the axis of the 3D Orthogonal Route display against existing geometry. Use Parallel With Edge and Perpendicular to Face to do so. When the next route point is defined on this axis, a parallel or perpendicular constraint is added to the resultant route segment. You can also pick up route points in the other two axes.
Applying the two commands can request an irregular angle (other than 45-degree and 90-degree) at the preceding route point. Consequently, a custom bend is created. Radius arrow and rotation arrow are available on the 3D Orthogonal Route display. Edit the bend radius and rotation angle as needed.