The active viewport can be split into multiple viewports using the Split method.
This method takes one parameter, the type of configuration to split the viewport into. To specify the window configuration, use one of the following constants that correspond to the default configurations previously shown: acViewport2Horizontal, acViewport2Vertical, acViewport3Left, acViewport3Right, acViewport3Horizontal, acViewport3Vertical, acViewport3Above, acViewport3Below, or acViewport4.
The following example creates a new viewport and then splits the viewport into two horizontal windows.
Sub Ch3_SplitAViewport()
' Create a new viewport
Dim vportObj As AcadViewport
Set vportObj = ThisDrawing.Viewports.Add("TEST_VIEWPORT")
' Split vportObj into 2 horizontal windows
vportObj.Split acViewport2Horizontal
' Now set vportObj to be the active viewport
ThisDrawing.ActiveViewport = vportObj
End Sub