By default, a new drawing has two layouts named Layout1 and Layout2, which you can rename.
You can add new layouts or copy existing layouts. You can create layouts using the Create Layout wizard or DesignCenter. Each layout can contain different page setup settings. However, to avoid confusion when transmitting and publishing drawings, it is usually recommended that you create only one named layout for each drawing.
On each layout, you can create as many layout viewports as you like. Each layout viewport is like a picture frame into model space, containing a view that displays the model at the scale and orientation that you specify. You can create a single layout viewport that fits the entire layout or create multiple layout viewports. Once you create a viewport, you can change its size, properties, and also scale and move it as needed. You can also specify which layers are visible in each layout viewport.