When you paint a stroke on a paintable object, the tube growth is relative to the surface normal. You may find yourself painting on surfaces with reversed normals (for example, if you are painting on a model where one side is a mirror of the other), in which case the tubes will grow in the opposite direction.
To remedy this, create a hotkey that you can use to switch the Opposite flag for the surface before you paint on it. Switching the flag for the surface after painting a stroke will have no effect on the existing stroke.
To create a hotkey for switching the Opposite flag
When the command is correctly selected, on the right side of the table row you see a flashing cursor, ready for you to enter an available hotkey combination.