A material node is "hot" when the material in the node is assigned to one or more surfaces in the scene.
When you use the Slate Material Editor to adjust a hot material node, the material in the scene changes at the same time.
In the title bar of the node, the corners of the material preview indicate whether the material is a hot material:
A material is "cool" if it is not applied to any object in the scene.
To make a hot material node cool, clone it by using Shift+drag or Ctrl+Shift+drag. This makes a copy of the material (or of the material plus its maps) that is not used in the scene.