The Edit Spline modifier provides explicit editing tools for different levels of the selected shape: vertex, segment, or spline. The Edit Spline modifier matches all the capabilities of the base Editable Spline object, with the exceptions noted below. For a complete parameter reference, see Editable Spline.
The Rendering and Interpolation rollouts found in Editable Spline, which allow manipulation of the spline's creation parameters, are not available in the Edit Spline modifier. (The creation parameters are available in the modifier stack for a spline to which Edit Spline is applied.) In addition, the direct vertex animation capabilities of Editable Spline are not possible in Edit Spline.
When possible, it’s far more efficient and reliable to perform explicit editing at the Editable Spline level rather than store those edits within the Edit Spline modifier. The Edit Spline modifier must copy the geometry passed to it, and this storage can lead to large file sizes. The Edit Spline modifier also establishes a topological dependency that can be adversely effected if earlier operations change the topology being sent to it.
There are, however, situations where using Edit Spline is the preferred method.
To extrude spline segments or vertices
To clone spline segments