You can rotate an entire view within a layout viewport with the VPROTATEASSOC system variable.
When VPROTATEASSOC is set to 1, the view within a viewport is rotated with the viewport. When VPROTATEASSOC is set to 0, the view remains when the viewport is rotated.
You can also rotate an entire view within a layout viewport by changing the UCS and using the PLAN command.
With the UCS command, you can rotate the XY plane at any angle around the Z axis. When you enter the PLAN command, the view rotates to match the orientation of the XY plane.
Note: The ROTATE command rotates individual objects only and should not be used to try to rotate a view.