There are two types of reactors that you can create: transient or persistent.
Transient reactors are lost when a drawing closes; this is the default reactor mode. Persistent reactors are saved with the drawing and exist when the drawing is next opened.
You can use the following functions to make and remove persistent reactors:
(vlr-pers circleReactor) #<VLR-Object-Reactor>
(vlr-pers-list) (#<VLR-Object-Reactor> #<VLR-Object-Reactor> (#<VLR-Object-Reactor>) (vlr-pers-list :VLR-DWG-Reactor) nil
(vlr-pers-p circleReactor) #<VLR-Object-Reactor>
(vlr-pers-release circleReactor) #<VLR-Object-Reactor>