There are various ways to launch an analysis. The most appropriate one will depend upon your setup.
The usual method of launching an analysis on a Windows OS is from the Home tab of the Navigation ribbon.
Alternatively, you can submit analysis jobs using the Job Manager dialog.
An analysis can also be launched from the command line using a utility called runstudy, which is installed with the software. For full details on this utility, including a parameter to specify the directory where the temporary files of the analysis are created, enter runstudy without any parameters at the command prompt.
If your solvers are installed on a Linux OS, you can launch your analyses from the command line on Linux.