Maya 2022.3 provides Substance 2.2.1 that includes a new Substance Engine, Arnold support and an improved user interface.
Substance 2.2.1 includes the newest Substance Engine 8.3.0 - it supports assets from Substance 3D Designer, Substance 3D Assets, and Substance 3D Sampler; the ability to render your scene directly with multiple versions of Arnold, including the latest version MtoA 5.0.0, and an improved user interface that provides the ability to manage and edit renderer workflows.
For a list of features, visit http://www.autodesk.com/maya-substance-docs.