For example, you can use Bottom up to cut this glider mold part:
After a Z-level rough and a 2.5D finish, a Z-level finish strategy is used, with Scallop height to control the shape of the toolpath.
This is a 3D simulation with Bottom up deselected:
The Ball End Mill tool (shown in yellow) starts at the top in the middle cutting outwards and so is cutting with the center of the tool:
This is the result with Bottom up selected:
The tool starts at the bottom outside of the slope and mills upwards and inwards towards the center so that the side of the tool is used, which has a better cutting surface.