On the Manufacture workspace toolbar, click Milling > Drilling > Drill.
The Drill dialog opens.
On the Tool tab, click Select to pick a tool. In the left panel of the dialog, from the Fusion Library, pick a tool from the Sample Tools library.
(Optional) On the Multi-Axis tab, in the Machining Type group, select a machining type. You can choose 4-axis or 5-axis machining.
On the Geometry tab, you can select the hole locations by picking cylindrical hole faces from the model, hole edges, sketch geometry and points.
For 4-axis machining, you can select holes that are not aligned with the Z-axis, such as angled holes or holes on a sloped surface:
For 5-axis machining, you can select complex hole geometries that require the tool to tilt to access certain areas.

Optional steps:
To select holes of the same size, enable the Select Same Diameter parameter.
To select holes of the same depth, enable the Only Same Hole Depth parameter.
To select holes at the same starting height, enable the Only Same Z Top Height parameter.
On the Heights tab, set the Bottom Height if the geometry selection is based on hole edges or sketch geometry. If Faces were selected, Fusion recognizes the Hole Bottom automatically from the model data.
On the Passes tab, adjust any cycle specific parameters as needed for your operation.
On the Cycle tab, select the Cycle Type based on the type of hole being created.
Click OK.
The toolpath is generated based on the selected machining type and geometry.

3-axis Drilling toolpath.
Multi-axis Drilling toolpath.